Diazepam se ne sme primenjivati kao jedini lek u terapiji depresije ili anksioznosti udružene sa depresijom, jer kod ovih pacijenata može da se izazove suicid.oralni kontraceptivi, (pilule za sprečavanje začeća) jer mogu da uspore izlučivanje diazepama iz organizma i pojačaju njegovo dejstvo. Može doći do pojave probojnog krvarenja pri ist
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